Titanium metal?organic frameworks (MIL?125(Ti)) were used as the core and shell materials.On this basis,a core?shell material with larger and more uniform particle size denoted as MIL?125(Ti) coated MIL?125(Ti) (MOFs@MOFs) was synthesized by the epitaxial growth method, which was then calcined to obtain micron?sized chromatographic packing TiO₂.The preparation conditions,incuding adding amount of core materials,dilution times of shell solution,reaction time,and coating layers,were investigated,which were optimized to be that the amount of core was 30 mg,the shell solution should not be diluted,the reaction time was 24 h,and the coating layer was 1 layer.The results showed that the anatase TiO₂ materials with a specific surface area of 76.0 m²/g,a particle size of about 7 μm,and a thickness of about 2.5 μm,were successfully prepared by MOFs@MOFs,The synthesized TiO₂ not only retained the excellent performance of MOFs@MOFs but also featured a large particle size and adjustable porous structure.In addition,the method was easy to operate without demanding synthesis conditions,and had strong operability.